CCL27 and HIV infectious disease: In conclusion, our data show four key findings: (1) there are constitutive differences in chemokines between outer and inner foreskin tissue; (2) that a urethral STI is able to induce inflammation in a distal location of the foreskin, and that these changes are found in both the outer and inner foreskin; (3) the inner foreskin may be more susceptible to HIV infection due to increased proximity of HIV target cells to the surface of the tissue and (4) this increased proximity may be due to differences in CCL27 expression between the outer and inner foreskin.