First, that the density of the dual-expressing CD4+CCR5+ cells was enriched in the epithelium of both the outer and inner foreskin in the presence of STIs; second, that > 90% of CD4+ T cells co-expressed CCR5 in the epithelium, being in agreement with Prodger et al.15 who showed that CD4+CCR5+ cells were more than fourfold abundant in the foreskin tissue relative to the peripheral circulation. The gene discussed is CD4; the disease is sexually transmitted disease.