The abnormal lipid metabolism in Mets is characterized by elevated VLDL, hypertriglyceridemia, high levels of LDL-C, increased CETP activity, and low levels of HDL-C, in which insulin resistance and increased circulating free fatty acid (FFA) resulting from adipose tissue hyperplasia and hypertrophy are considered as fundamental pathogenesis12–15. The gene discussed is CETP; the disease is hypertriglyceridemia.