Several genes involved in the control of infectious diseases such as the basic leucine zipper transcription factor 2 (BATF2) and CXCL10 chemokine were found in our study highly upregulated in the PB and ICV gene expression profiles from the cows with diffuse lesions versus the control group but were unaffected in the cows with focal lesions. Here, CXCL10 is linked to infectious disease.