The tumor volume of three groups were measured at 6 weeks, the result showed that the B7-H4 siRNA-2 group were 1211 ± 193.1 mm3, 1730 ± 98.57 mm3 in the non-target siRNA group and 1700 ± 58.86 mm3 in the blank control group, while the corresponding weight were 777.7 ± 114.0 mg, 1186 ± 133.5 mg and 1181 ± 95.73 mg respectively. This evidence concerns the gene VTCN1 and neoplasm.