In contrast, resistance toward 5-FU was higher for CD44+ CD133+ DLD-1 cells (IC50 = 5.5 μM) than for unsorted DLD-1 cells (IC50 = 2.5 μM); the fold-change in IC50 was 2.2 for 5-FU and 1.2 for FTD (Fig. 2b). Here, PROM1 is linked to frontotemporal dementia.