Additionally, AUROC analyses found PRO-C4 and C4M to be the best markers for detecting fast progressors towards cirrhosis from non-progressors at baseline with AUCs of 0.90 [95% CI 0.7–0.9] and 0.88 [95% CI 0.6–0.9], and specificities >80% (Table 2). This evidence concerns the gene C4A and Cirrhosis.