In a cohort of 144 MM patients compared to 237 matched healthy individuals, two SNVs (rs711613C > T and rs1045433C > T) within the non-coding regions of the CRBN gene (intron 1 and 3′-untranslated region, respectively), thought to control CRBN expression, correlated with major differences in MM susceptibility, progression, and response to treatment26. This evidence concerns the gene CRBN and Miyoshi myopathy.