The major IFNL3 rs12979860 CC genotype previously associated with liver fibrosis was present at a significantly higher frequency in SSc patients with pulmonary fibrosis compared to those without (29% vs 21%, OR: 1.51 (95% CI: 1.077–2.119, p = 0.01). This evidence concerns the gene IFNL3 and Hepatic fibrosis.