Importantly, increased cytoplasmic circNSUN2 substantially enhances the stability of high mobility group AT-hook 2 (HMGA2) mRNA through interaction with an RNA-binding protein (RBP), Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), which consequently leads to the aggressive nature of CRC cells. This evidence concerns the gene HMGA2 and colorectal carcinoma.