VIM and colorectal carcinoma: Western blot (WB) showed that overexpression of circNSUN2 led to the downregulated expression of the epithelial marker E-cadherin, and upregulated expression of the mesenchymal marker, Vimentin, in CRC cells (Supplementary Fig. 5c), suggesting that circNSUN2 promotes EMT in CRC cells through HMGA2 pathway.