Furthermore, the expression of lncRNA MALAT1 as well as those of inflammatory cytokines including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 was found to be up-regulated in DCM, and the down-regulation of lncRNA MALAT1 was accompanied by decreased concentration of these cytokines, suggesting that lncRNA MALAT1 is very likely to participate in the inflammatory progression of DCM [12]. The gene discussed is TNF; the disease is familial dilated cardiomyopathy.