VIM and infection: When the composition of the vimentin network was thoroughly analyzed using confocal microscopy, it was noticed that at later stages of infection, when the cytoplasm was full of newly synthetized capsid proteins (4 to 6 h postinfection [p.i.]), the majority of the infected cells showed drastic vimentin rearrangements, leading to the formation of a compact vimentin cage next to the nucleus (Fig. 1A).