APOE and ischemic stroke: In a pooled analysis, where associations between APOE genotype and several biomarkers were investigated, there was an apparent dose-response segregation of low-density lipoprotein cholesterol concentrations by APOE genotype, with the highest values in subjects homozygote for the APOE ε4 allele.8 Furthermore, the same ordering was observed for increasing carotid intima-media thickness and risk of ischemic stroke.8