To validate our findings from the sequencing data and study their role in CRC, the top eight of over two-fold enrichment of cancer-related lncRNAs in the YAP-bound portion compared with IgG antibody using qRT-PCR and agarose gel electrophoresis were analyzed further for conservation across species, transcript abundance in CRC cells, and the effects on YAP nuclear translocation (Fig. 1b-g, Additional file 1: Figure S1). The gene discussed is YAP1; the disease is colorectal carcinoma.