However, amongst the 186 women with HPV-16 and/or 58 infection, the sensitivity of the HPV-16 and/or 58 load/p16/Ki-67 co-test was higher for CIN and more severe lesions when compared to p16/Ki-67 co-testing alone. The gene discussed is MKI67; the disease is cervical squamous intraepithelial neoplasia.