However, amongst those patients with HPV-16 and/or 58 infection, a combination of the HPV-16 and/or 58 DNA load with p16/Ki-67 staining increased the sensitivity of the detection of CIN1+ and CIN2+ lesions, though p16 and Ki-67 tests were proven to be a highly sensitive method to estimate CIN2+ cytological cases [9, 22, 23]. This evidence concerns the gene MKI67 and infection.