MKI67 and cervical squamous intraepithelial neoplasia: The coexpression of p16 and Ki-67 was developed as an auxiliary marker of cervical precancers [11, 12], but a series of studies reported that an increased risk of high-grade CIN or CCa is associated with high HPV DNA loads [15, 16], suggesting that HPV is a marker to predict cervical neoplasia.