Previous study has shown that Sor-induced Akt, ERK and VEGFR2 activation has been reported in both Sor-resistant and parental HCC cells [3, 4, 11] and that increased p-Akt, p-ERK and p-VEGFR2 expression is responsible for resistance to Sor. This evidence concerns the gene AKT1 and hepatocellular carcinoma.