Vaso-occlusion is the primary indicator of SCD and can lead to serious acute and chronic complications; vascular dysfunction, inflammation, and P-selectin mediated cell-to-cell and cell-to-endothelium adhesion play an important role in the pathophysiology of SCD vaso-occlusive crisis (VOC), which is the most common clinical manifestation of SCD. This evidence concerns the gene SELP and Schnyder corneal dystrophy.