Given that ADRB2 stimulation may provide several benefits to respiratory function (e.g., increased diaphragmatic contractility, improved mucocilliary clearance, inhibited inflammatory pathways and calpain activity), we hypothesized that DMD patients with the more “functional” ADRB2 polymorphism (i.e., Gly16) would demonstrate a lower risk of NV use compared with DMD patients expressing the less functional polymorphism (i.e., Arg16). Here, ADRB2 is linked to Duchenne muscular dystrophy.