FGFR3 expression in malignant melanoma tissues was correlated with lymph node metastasis, which is in agreement with the observation that FGFR3 is expressed more in metastatic melanoma cells than primary tumor cells [28], and that the activation mutation of FGFR3 can be associated with metastasis in many types of cancer. This evidence concerns the gene FGFR3 and cancer.