A total of 309 downregulated genes were common between BBI608 and YM155 treatments (Fig. 3f and Additional file 6: Table S6); these genes were associated with pathway with cancer and the ERBB signaling pathway, which included ERBB3 (HER3) and BIRC5 (Survivin) (Fig. 3g), whereas BIRC5 was previously identified as an inhibitory gene of YM155 [32]. The gene discussed is EGFR; the disease is cancer.