In our permeability assays, we had found that ADAM10 as well as ADAM17-inhibitors prevented an irradiation-induced increase in permeability of endothelial cell monolayer for macromolecules, but only the ADAM10 inhibitor was able to counteract VE-cadherin cleavage and transendothelial migration of MDA-MB-231 breast cancer cells. This evidence concerns the gene ADAM17 and breast cancer.