Binding of estrogen with ERs in the cytoplasm induces homo- or heterodimerization of ERs, and the complex of estrogen and ERs translocates to the nucleus where it binds to specific DNA sequences, known as estrogen response elements (EREs), and regulates the transcription of target genes, such as ATP binding cassette subfamily A member 3 (ABCA3) and growth regulation by estrogen in breast cancer 1 (GREB1) [93,94,95] (Figure 1A). Here, ABCA3 is linked to cancer.