It has been published that suppressive effects of neutralizing antibody 1D11 has suppressive effects on human breast cancer cell line MDA-MB-231 [39], and that SD-208, an inhibitor of TGF-β receptor 1 kinase (TβR1-Ki) suppressed the development of melanoma bone metastasis [40] in the series of an in vivo study. Here, TBR1 is linked to melanoma.