In BC, key insights were recently provided by Fluegen et al., who showed that the primary tumor hypoxic microenvironment contains a subpopulation of tumor cells that are characterized by the combined activation of hypoxia (glucose transporter 1/GLUT1, HIF1α) and dormancy (nuclear receptor subfamily 2 group F member 1 NR2F1 and p27) genes. Here, HIF1A is linked to neoplasm.