6-Shogaol also increased the phosphorylation of p38 and ERK MAPKs, and slightly elevated JNK phosphorylation in human breast cancer cell [51], and specific inhibitors of p38 (SB202190) and PI-3K (LY294002) suppressed 6-shogaol-induced Nrf2 translocation into the nucleus in human colon cancer cells [52]. The gene discussed is MAPK8; the disease is breast cancer.