Ginger extract inhibited NF-κB activity and decreased IL-8 and vascular endothelial growth factor secretion in an ovarian cancer cell line [54], and Zingiber officinale decreased nuclear NF-κB levels in the livers of high-fat diet-fed rats and IL-1β-induced IL-6 and IL-8 expression levels by downregulation of NF-κB activity in human hepatocytes [55]. The gene discussed is IL6; the disease is ovarian cancer.