HMOX1 and atopic eczema: 6-Shogaol inhibited ROS production and activated HO-1, NQO1, and Nrf2 in vitro and ameliorated experimental allergic dermatitis-like skin lesions in vivo [46], and it suppressed Nrf2 expression in the kidney and decreased the levels of blood glucose and HbA1c in diabetic mice [40].