Mutations in epigenetic regulators such as enhancer of zeste homolog 2 (EZH2), additional sex combs like 1 (ASXL1), and a splicing factor, arginine/serine-rich 2 (SRSF2), are associated with poor prognosis and risk of AML transformation [2]. This evidence concerns the gene EZH2 and acute myeloid leukemia.