To investigate the molecular basis for the anti-obesity effect of GPE, we measured the expression of adipogenic transcription factors, including CCAAT/enhancer binding proteinα (C/EBPα), peroxisome proliferator-activated receptor-γ (PPARγ), and sterol regulatory element-binding protein-1c (SREBP-1c) as well as their target genes in epididymal adipose tissues. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.