A meta-analysis based on nine studies of HCC patients treated with sorafenib suggested that higher VEGF levels were associated with both poorer progression-free (HR=2.09; 95%CI = 1.43–3.05; p < 0.01) and overall survival (HR = 1.85; 95%CI = 1.24–2.77; p = 0.003) [63]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.