The high expression of p53 protein is a favorable prognostic factor in a subset of patients with NSCLC [54], whereas the exon 8 mutation of p53 gene reduces the responsiveness to tyrosine kinase inhibitors (TKIs) and worsens prognosis in EGFR-mutant NSCLC patients [55]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.