Resveratrol treatment causes induction of p53, p21 and BRCA in breast cancer cells [126,127,128] via various pathways, one important mechanism being the modulation of epigenetic modulators protein arginine methyltransferase 5 (PRMT5) and enhancer of Zeste homolog 2 (EZH2) and causing changes in histone methylation marks [128]. The gene discussed is PRMT5; the disease is breast cancer.