Investigating the chemopreventive potential of genistein, Katdare et al., showed that genistein can modulate cell cycle progression and induce apoptosis in 184-B5/HER breast epithelial cells, a model for comedo-form ductal carcinoma in situ (comedo-DCIS) via downregulation of Her2/neu signaling cascade, upregulation of p16INK4 and BCL2 [178]. The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.