BITC mediated apoptotic-induction in breast cancer cells involves reactive oxygen species generation, increase in pro-apoptotic proteins such as Bax/Bak, reduction in anti-apoptotic proteins such as Bcl-2/Bcl-xL and activation of caspases including caspase 9, caspase 3, and caspase 8 [87]. The gene discussed is CASP3; the disease is breast carcinoma.