PRNP and lung adenocarcinoma: Knockdown of PrPc expression decreases lung adenocarcinoma cells’ lamellipodium formation, in vitro migration, and invasion, as well as in vivo experimental lung metastasis, which is associated with reduced JNK phosphorylation and reduced protein levels of a transcriptional activator of the PRNP promoter, namely, the nuclear factor interleukin 3 (NFIL3) [64].