PRNP and pancreatic ductal adenocarcinoma: This applies to both hematopoietic and solid tumors, where PrPc is markedly overexpressed, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, gastric and colorectal cancer, and gliomas [21,22,23,24,25,26,27,28,29,30,31,32].