TGFB1 and cancer: The choice to use this phenotype to classify cases putatively responsive to ICI could be considered in keeping with the fact that when primary cases of all the 29 TCGA cancer types were simultaneously considered, TMB/TGF-β- score positive cases showed significantly longer OS, DSS and PFI intervals than TMB/TGF-β score negative cases, irrespective of the type of cancer, the clinical and molecular features and the treatment managements of the analyzed cases (Figure 1).