TGFB1 and cancer: To evaluate the immune-related features of gene expression signatures of TMB/TGF-β score positive cases, we classified the cases included in the study according to the six immune subtypes defined in Thorsson et al. [17], where a multi-omic analysis of TCGA datasets allowed the definition of subtypes ( C1 (wound healing), C2 (IFN-γ dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), C6 (TGF-β dominant) ) useful to classify cancer cases across different cancer types according to distinct immune signatures.