A recent elegant study contributed to unraveling the mechanisms by which vitamin E improves renal function: The authors demonstrated in animal models that the amelioration of DKD induced by vitamin E supplementation was mediated by the activation of diacylglycerol kinase, an enzyme that, by reducing circulating levels of diacylglycerol, prevented abnormal activation of PKC and the regression of podocytes [39]. Here, PRRT2 is linked to diabetic kidney disease.