The results of meta-analysis demonstrated that patients with high density of CD68+ TAMs in IT were associated with high AFP value (pooled OR = 1.31, 95% CI = 1.07–1.61; P = 0.01), large tumor size (pooled OR = 1.46, 95% CI = 1.19–1.79; P < 0.01), absent encapsulation (pooled OR = 0.77, 95% CI = 0.61–0.96; P = 0.02), present vascular invasion (pooled OR = 1.33, 95% CI = 1.03–1.71; P = 0.03), and later TNM stage (pooled OR = 1.51, 95% CI = 1.17–1.95; P < 0.01). Here, CD68 is linked to neoplasm.