NLRP3 and mood disorder: Another possible explanation for a higher risk of suicide among users of ARBs is associated with the upregulation of AII and resulting unopposed stimulation of AII type 2 receptors.1 These effects have been associated with nuclear factor–κB pathway activation,20 a process increasingly recognized as being involved in the pathophysiology of mood disorders.21,22 The mechanisms linking ARBs to mental health conditions and whether these effects are common to all members of this class are areas where further research is required.