The Caucasian kindred had one homozygous and seven heterozygous individuals caused by two separate deleterious LDLR variants (exon 1 3kb deletion and p.G592E), with the possibility that a putatively deleterious novel APOB variant (p.G230V) contributes to the severity of FH in this family. This evidence concerns the gene APOB and familial hyperaldosteronism.