Among the other potentially damaging variants, MYL5 (myosin light chain 5) p.F88S, is in a gene that is one of 10 shown to be regulated by the master trans regulator KLF14 (Consortium et al., 2011), itself associated with levels of HDL‐C (Lange et al., 2015) and type 2 diabetes. This evidence concerns the gene KLF14 and type 2 diabetes mellitus.