Recently, it has been demonstrated that PDGF signaling (PDGF‐CC/PRGFRα) may become induced downstream of tPA as a consequence of tPA‐mediated cleavage and activation of latent PDGF‐CC, and that modulation of PDGF may improve post‐stroke BBB function 175. The gene discussed is CXCR1; the disease is Stroke.