Activation of the mitochondrial permeability transition pore (MPTP) by AMP is hypothesized to lead to apoptosis and necrosis.21, 22 In the brain, a lack of CNPase leads to increased susceptibility to brain damage and neurological diseases.23 Surprisingly, the lack of CNPase in the kidney protects against kidney damage, possibly by preventing the formation of 2'‐AMP and reducing mitochondrial damage.24, 25 Therefore, the exact roles of 2',3'‐cNMP and its downstream metabolites remain to be fully elucidated. Here, CNP is linked to nervous system disorder.