BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Previous investigations have shown that the transformation of BCR‐ABL oncogene can promote the generation of ROS and redox imbalance.15, 16, 17 However, others have incriminated the overproduction of ROS in the CML cells and exogenous ROS in the development of CML as well as in the resistance to IM.