ABL1 and cancer: It is well known that overproduction of ROS such as superoxide radicals (O2•−), hydrogen peroxide (H2O2), and the highly reactive hydroxyl radicals (OH•) leads to the oxidative damage of lipids, proteins, and DNA.35, 36 If not repaired DNA damage may bring mutagenesis and cause the onset or the development of different types of cancers,36, 37, 38, 39 high ROS level was particularly incriminated in the resistance to BCR/ABL kinase inhibitors established in experimental cell lines.