Another study that classified COF in cysts and young cysts (follicular structures >15 mm within 3–5 day of removal of previous cyst) reported an increase in StAR mRNA expression in the granulosa cells of cows with cysts, but not with young cysts, suggesting that the stages of development of the cyst might influence the characterization of steroidogenic disturbances reported in COF (37). The gene discussed is STAR; the disease is cyst.