Other possible pharmacological therapies include anti-diabetic drugs such as metformin, SGLT2 inhibitors, PPARγ and GLP-1 agonists, lipid lowering medications mainly statins as well as renin angiotensin system inhibitors due to their effect in reducing cardiovascular risk especially in the presence of dyslipidemia, diabetes and hypertension. This evidence concerns the gene PPARG and diabetes mellitus.