EphA3 is highly expressed on the tumour-initiating cell population in glioma, maintains tumour cells in a less differentiated and stem cell-like state, and its expression mediates the tumourigenic potential in GBM cells in vitro (26), suggesting that EphA3 may be a potential target for the treatment of GBM (Table 2). This evidence concerns the gene EPHA3 and central nervous system cancer.