AGO1 and neoplasm: Altogether, the evidence suggests that the miRNAs and 5′ tRNA halves (in particular 5′ tRNA-Val-CAC-2-1 half) belonging to the oncogenic Green module may function, at least in part, by downregulating the expression of AGO1 and consequently downregulating the expression of a subset of tumor suppressors 5′ tRNA halves.