We also found that the 5′ tRNA-Val-CAC-2-1 half belonged to a key miRNA-enriched regulatory coexpression module (denominated Green module) that was upregulated in the cancer tissue and targets genes involved in the negative regulation of the G1/S transition of the mitotic cell cycle and cell differentiation, namely FBXO31, WEE1, RB1, and E2F1. The gene discussed is E2F1; the disease is cancer.