TNFRSF4 and neoplasm: CARs contain an extracellular tumor antigen-recognizing scFv linked to an intracellular signaling component comprised of T-cell receptor (TCR) primary domain and often encompassing additional co-stimulatory endodomains (e.g., CD28, CD137 (4-1BB), CD134 (OX40), CD27, ICOS, etc.)(105).