A recent study showed that cervical squamous cell carcinoma (CSCC)-secreted exosomal miR-221-3p could transfer into LECs to promote lymphangiogenesis and lymphatic metastasis through downregulation of VASH1, representing a novel diagnostic biomarker and therapeutic target for metastatic CSCC patients in early stage (110). This evidence concerns the gene VASH1 and skin squamous cell carcinoma.