IFNG and primary cutaneous T-cell non-Hodgkin lymphoma: Notably, administration of IFN-α or IFN-γ, both of which have been approved for use in the treatment of CTCL, has been shown to modulate the chemokine profiles of TAMs in the lesional skin of CTCL (20), suggesting that re-polarization of TAMs into anti-tumor macrophages might be one of the possible mechanisms of anti-CTCL drugs.