We examined the correlation between extracellular vesicle-related genes and tumor purity as well as immune and stromal scores in CGGA and TCGA datasets and determined that ITGB5 is the only gene that is significantly correlated with all three factors along with unfavorable survival of GBM patients based on a univariate Cox regression analysis (P < 0.01; Figures 1E,F; Figure S1; Table S4). The gene discussed is ITGB5; the disease is glioblastoma.