CD8A and malignant colon neoplasm: In recent years, immune score system based on quantification of CD3+ and cytotoxic CD8+ T cells densities in the tumor and in the invasive margin has been proved to be a robust prognostic biomarker for colon cancer and other solid cancers (Hendry et al., 2017a; Hendry et al., 2017b; Pages et al., 2018).