CD3+ TILs in the central tumor area (p = 0.010), CD4+ TILs in the central tumor area (p = 0.045), CD8+ TILs in the central tumor area (p = 0.033), and CD8+ TILs in the invasive margin area (p = 0.004) also showed significant difference between lVI(-) and LVI(+) patients. Here, CD4 is linked to neoplasm.