CD4 and Opportunistic infection: Additionally, they had a median CD4 count of 281 cells/mm3 and therefore were still at low risk for opportunistic infections.31 This is supported by the low prevalence of a history of tuberculosis in the ART-naïve group compared to the group on first- and second-line ART, which might indicate that ART-naïve participants had not had uncontrolled viremia for a long period of time.