MEG3 and osteosarcoma: In retinoblastoma, HOTAIR, THOR, and MEG3 appear to have a similar influence as seen in osteosarcoma, where they also acted as oncogenes (HOTAIR and THOR) or tumor suppressors (MEG3) (Gao et al., 2017; Shang, 2018; Yang G. et al., 2018).