MYCN and neuroblastoma: In particular, loss of 1p36 occurs in 20–30% of neuroblastoma cases and correlates with MYCN amplification (Caron et al., 1993; Maris et al., 1995), whereas loss of 11q23 in occurs in approximately 40% of cases but almost never occurs with MYCN amplification (Figure 1A) (Guo et al., 1999; Attiyeh et al., 2005).