In addition, blocking the β-catenin pathway enhances the influx of CD8+ T cells and increases IFNγ-related gene targets in syngeneic murine models of B16F10 melanoma, 4T1 mammary carcinoma, Neuro2A neuroblastoma, and Renca renal adenocarcinoma (32). The gene discussed is CD8A; the disease is melanoma.